This first issue of 2025 begins with a highly relevant editorial titled “Mental Health 4.0: The Contribution of LLM Models in Mental Health Care Processes”, in which the author explores the potential of Artificial Intelligence in mental health services through a critical analysis and an invitation to ethical awareness. The first article in this issue, “Changing Emotion with Emotion”, has a strong international scope and cultural depth. We are honored to feature it by invitation from Professor Leslie Greenberg. In this article, the Emotion-Focused Therapy approach is introduced, with Professor Greenberg widely acknowledged as its primary developer. The second article, an opinion piece by Bifulco et al., is titled “Climate Crisis Between Emotional and Social Consequences: A Focus on Clinical-Community Implications”. The authors explore new specific emotional responses resulting from the technological revolution. By examining their clinical and social implications, they propose new therapeutic treatment perspectives and targeted community support systems. The third article, by Lazzaroni et al., titled “Treatment of Common Emotional Disorders in Integration with Primary Care: An Innovative Intervention Model within a Local Health Authority”, presents a treatment model for common emotional disorders based on a stepped-care approach, with progressively increasing intervention gradients. This model is inspired by the principles of collaborative care and stepped care. The fourth and final article of this first issue of the year, authored by Ani Rainauli and titled “Through the Eyes of Gestalt Therapy: The Emergence of Existential Experience on the Contact Boundary”, aims to demonstrate the importance of existential integration in Gestalt therapy practice. The article presents two clinical cases where the therapist’s role in supporting patients’ existential needs within the contact cycle proved essential. In conclusion, we believe this new issue represents an important step toward a more complex and integrated approach to psychotherapy. By bringing together international scholars and leading professionals from different fields, we hope to foster interdisciplinary dialogue and collaboration and contribute to the development of more effective and personalized interventions that address the complexity of human experience. We hope that this new issue will inspire future research and clinical practice and help improve the lives of individuals and communities worldwide.